Peptides To Lose Weight [Updated 2024]: A Comprehensive Guide to Weight Loss

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If you are trying to lose weight but struggling to do so through diet and exercise alone, peptide therapy may be an option for you. This article explains how peptides work, their side effects, and the different types of peptides available on the market.

Nowadays, there are a huge number of weight loss tips available in the market. It can be hard to know where to turn or who to trust. Peptide therapy has been proven to aid weight loss, in addition to its many other benefits.

What are peptides?

Peptides are short chain amino acids linked by peptide bonds. They are smaller and smaller than proteins, and they are found in the cells and tissues of the body. Peptides are used in many physiological processes for the growth, development and survival of cells.

In addition to natural peptides in the body, peptides are also found naturally in food sources such as meat, fish, beans, lentils, and oats. Synthetic peptides are used for diagnostic and therapeutic purposes.

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How Weight Loss Peptides Work?

Weight loss peptides work through several mechanisms. They are similar in structure to naturally produced peptides. This means they can bind to the same receptors in your body and have similar effects. Drugs that bind to receptors similar to naturally produced proteins are called receptor agonists.

An important weight loss peptide, glucagon-like peptide-1 (GLP-1), and its receptor agonists have been shown in clinical trials to reduce appetite, make people feel full, and increase insulin release. This combination may reduce calorie intake and increase the body’s ability to use glucose effectively.

GLP-1 is produced in the gut after you eat and has the following roles in your body:1

  • Stimulates insulin release: Insulin helps reduce your blood sugar levels by ushering glucose from the bloodstream into the liver and body cells. GLP-1 receptor agonists are used to treat type 2 diabetes.
  • Inhibits glucagon secretion: Glucagon raises blood sugar levels, and GLP-1 suppresses glucagon release from the liver.
  • Slows stomach emptying: GLP-1 slows how fast food is moved from your stomach and through your intestines. This can help you feel full longer.
  • Reduces appetite: GLP-1 acts in the brain to reduce appetite and increase satiety.
  • Has cardiovascular benefits: Clinical studies suggest that GLP-1 reduces the risk of heart and blood vessel disease.
  • Decreases fat storage: GLP-1 reduces lipogenesis. This is when your body stores excess energy as fat.
  • Has neurologic benefits: GLP-1 protects neurons (brain cells).

Similar to GLP-1, another weight loss peptide, glucose-dependent insulinotropic polypeptide (GIP), is released from the gut after you eat. GIP has the following roles in the body:2,3

  • Stimulates insulin release
  • Decreases appetite
  • Increases satiety
  • Increases glucagon secretion
  • Protects the heart and blood vessels
  • Promotes fat storage

Growth hormone-releasing hormones (GHRH) are hormones that stimulate the release of growth hormone from the pituitary gland. Growth hormones increase lean body mass and decrease fat mass. Naturally produced growth hormones generally decrease with age.

Growth hormone secretagogues stimulate the secretion of growth hormone. They work within your body’s natural feedback loops. These controls help protect your body from the effects of excessive growth hormone release.

The Best Weight Loss Peptides

While there are many effective weight-loss medications, here are four of the top peptides for weight loss.

1) Sermorelin

Sermorelin is a growth hormone-releasing peptide (GHRP) that stimulates the production and release of growth hormone. While primarily used for its muscle building properties, Sermorelin has also shown weight loss potential as it increases naturally produced growth hormone.

By increasing growth hormone levels, sermorelin boosts metabolism, promotes fat burning, and supports lean muscle development. Sermorelin is typically administered via subcutaneous injection.

Plan to give Sermorelin a four to six month trial to see its full effects. Besides weight loss, sermorelin has several other potential benefits for men and women.

2) Tirzepatide (Mounjaro)

Tirazeptide is a new GLP-1 and GIP receptor agonist approved by the FDA for the treatment of type 2 diabetes and obesity. Unlike semaglutide and liraglutide, tirazeptide targets obesity in two ways, via GLP-1 and GIP receptors, resulting in even greater weight loss.

In clinical trials, individuals taking tirazepate experienced significant weight loss. Participants taking tirazepate lost an average of 21% of their body weight over 72 weeks. In the second phase of the trial, they lost an additional 6.7% of their body weight over 84 weeks and lost 26.6% overall.

3) Liraglutide (Saxenda)

Liraglutide, sold as Saxenda and Victoza, is another GLP-1 receptor agonist approved by the FDA for the treatment of type 2 diabetes and obesity.

Similar to semaglutide, liraglutide helps reduce appetite and increase the feeling of fullness. Many people who take liraglutide say it helps them develop a healthy relationship with food. Food cravings and obsessive thoughts about food no longer control them.

Clinical studies have shown how effective liraglutide is in weight loss. Participants taking liraglutide consumed approximately 16% fewer calories and lost an average of 11 pounds more weight than participants not taking liraglutide.5

Liraglutide is given via injection once daily, making it a convenient option for individuals seeking permanent weight loss.

1. Semaglutide (Ozempic/Wegovy)

Semaglutide, marketed under the brand names Ozempic and Vegovy, is a GLP-1 receptor agonist approved by the FDA for the treatment of type 2 diabetes and obesity.

This drug, which is injected once a week, has shown remarkable results in weight loss clinical trials, with participants experiencing an average of 15% weight loss.4

Semaglutide works by stimulating insulin release, reducing appetite, and promoting feelings of fullness, making it a powerful tool for weight management. In addition to promoting weight loss, semaglutide may protect your brain and heart from damage caused by inflammation.

The Benefits of Peptides for Weight Loss

Peptides are small proteins designed to mimic the effects of proteins produced in your body. Sermorelin, semaglutide, liraglutide, and tirazeptide are all injectable. Like all medicines, they have risks and benefits.

1. Anti-Aging Benefits

In addition to weight loss, peptides have anti-aging properties that can improve skin elasticity, reduce wrinkles, and boost overall vitality. Peptide therapy can help you look and feel better as you work toward your weight loss goals.

Semaglutide, liraglutide, tirazepate, and sermorelin have risks and benefits and, therefore, are not ideal treatment options for everyone. Invigor Medical offers a wide range of weight loss options. Your Invigor Medical healthcare provider will evaluate your medical history and determine if you are a candidate for these weight loss peptides.

Schedule a consultation with a healthcare provider at Invigor Medical to learn more about your options for weight loss treatment.

Get started with one of our weight loss treatment plans today with weight loss peptides.

2. Increased Energy and Fitness Performance

Peptides can increase energy levels and improve physical performance, allowing you to engage in more vigorous exercise routines and burn more calories.

By optimizing energy levels, peptides can support your weight loss journey and overall fitness goals.

3. Improved Body Composition

Sermorelin and other growth hormone-releasing peptides may promote lean muscle growth and fat cell breakdown. This can improve body structure. After taking Sermorelin, you may be able to exercise for longer periods of time and burn more calories.

4. Reduced Appetite and Cravings

Some peptides, such as GLP-1 receptor agonists, may help curb appetite and reduce cravings, making it easier to stick to a healthy eating plan. When you don’t feel hungry and don’t have constant cravings for foods rich in fat, sugar and salt, you can lose weight and keep it off.

5. Better Blood Sugar Control

Semaglutide, liraglutide, and tirazepate increase insulin release and control your blood sugar. It may help reduce your risk of type 2 diabetes.

Studies show that these peptides may also reduce inflammation and protect your heart and blood vessels.

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Q) Can semaglutide (Ozempic) affect your fertility?

There is no evidence that semaglutide (Ozempic) negatively affects fertility, says Kadaj.

But there is a link between obesity and infertility. So, “in some cases, if a person is taking Ozempic and losing weight, it may actually improve fertility,” he says.

Q) What happens if you become pregnant while taking semaglutide (Ozempic)?

According to the drug’s prescribing information, pregnant rats, rabbits, and monkeys who received semaglutide (Ozempic) experienced higher rates of pregnancy loss, birth defects, and low birth weight.

It is unclear whether these effects are possible in humans. There are limited data on the use of semaglutide (Ozempic) in pregnant people.

Most health care professionals recommend against the use of semaglutide (Ozempic) during pregnancy.

If you are currently taking semaglutide (Ozempic) and test positive for pregnancy, consult your doctor as soon as possible. They can advise you on any next steps, including how to safely discontinue use.

Q) Can Wegovy or tirzepatide (Mounjaro) affect birth control efficacy?

Wegovi has the same active ingredient as Ozempic — semaglutide — so the potential risk of decreased birth control efficacy would be similar, Kadaj says.

“Monjaro has a similar mechanism of action to Ozempic, so its theoretical concerns would be similar,” he says.

The bottom line

Although it is possible that semaglutide (Ozempic) may interfere with your body’s ability to break down and absorb oral contraceptives, there has not been research to determine this.

If you use birth control pills and are considering semaglutide (Ozempic), talk to a health professional about the potential interaction and what it could mean for you, your overall health, and your risk of pregnancy. Consult a care professional.

In the meantime, if you currently use semaglutide (Ozempic) and are interested in hormonal birth control, you may consider the patch, implant, or IUD. Your doctor can help you determine which method best suits your needs.

Thank you for reading my blog of peptides to lose weight.

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